Significant Impact of Sequence Variations in the Nucleoprotein on CD8 T Cell-Mediated Cross-Protection against Influenza A Virus Infections
Identifieur interne : 000E23 ( Main/Exploration ); précédent : 000E22; suivant : 000E24Significant Impact of Sequence Variations in the Nucleoprotein on CD8 T Cell-Mediated Cross-Protection against Influenza A Virus Infections
Auteurs : Weimin Zhong [États-Unis] ; Feng Liu [États-Unis] ; Libo Dong [États-Unis] ; Xiuhua Lu [États-Unis] ; Kathy Hancock [États-Unis] ; Ellis L. Reinherz [États-Unis] ; Jacqueline M. Katz [États-Unis] ; Suryaprakash Sambhara [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2010.
Abstract
Memory CD8 T cells to influenza A viruses are widely detectable in healthy human subjects and broadly cross-reactive for serologically distinct influenza A virus subtypes. However, it is not clear to what extent such pre-existing cellular immunity can provide cross-subtype protection against novel emerging influenza A viruses.
We show in the mouse model that naturally occurring sequence variations of the conserved nucleoprotein of the virus significantly impact cross-protection against lethal disease
Pre-existing CD8 T cell immunity may provide substantial cross-protection against heterosubtypic influenza A viruses, provided that the priming and the subsequent challenge viruses share the identical sequences of the immunodominant, protective CTL epitopes.
Url:
DOI: 10.1371/journal.pone.0010583
PubMed: 20485501
PubMed Central: 2868023
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Significant Impact of Sequence Variations in the Nucleoprotein on CD8 T Cell-Mediated Cross-Protection against Influenza A Virus Infections</title><author><name sortKey="Zhong, Weimin" sort="Zhong, Weimin" uniqKey="Zhong W" first="Weimin" last="Zhong">Weimin Zhong</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Liu, Feng" sort="Liu, Feng" uniqKey="Liu F" first="Feng" last="Liu">Feng Liu</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Dong, Libo" sort="Dong, Libo" uniqKey="Dong L" first="Libo" last="Dong">Libo Dong</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Lu, Xiuhua" sort="Lu, Xiuhua" uniqKey="Lu X" first="Xiuhua" last="Lu">Xiuhua Lu</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Hancock, Kathy" sort="Hancock, Kathy" uniqKey="Hancock K" first="Kathy" last="Hancock">Kathy Hancock</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Reinherz, Ellis L" sort="Reinherz, Ellis L" uniqKey="Reinherz E" first="Ellis L." last="Reinherz">Ellis L. Reinherz</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. 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xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Liu, Feng" sort="Liu, Feng" uniqKey="Liu F" first="Feng" last="Liu">Feng Liu</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Dong, Libo" sort="Dong, Libo" uniqKey="Dong L" first="Libo" last="Dong">Libo Dong</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Lu, Xiuhua" sort="Lu, Xiuhua" uniqKey="Lu X" first="Xiuhua" last="Lu">Xiuhua Lu</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Hancock, Kathy" sort="Hancock, Kathy" uniqKey="Hancock K" first="Kathy" last="Hancock">Kathy Hancock</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Reinherz, Ellis L" sort="Reinherz, Ellis L" uniqKey="Reinherz E" first="Ellis L." last="Reinherz">Ellis L. Reinherz</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Sambhara, Suryaprakash" sort="Sambhara, Suryaprakash" uniqKey="Sambhara S" first="Suryaprakash" last="Sambhara">Suryaprakash Sambhara</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Memory CD8 T cells to influenza A viruses are widely detectable in healthy human subjects and broadly cross-reactive for serologically distinct influenza A virus subtypes. However, it is not clear to what extent such pre-existing cellular immunity can provide cross-subtype protection against novel emerging influenza A viruses.</p></sec><sec><title>Methodology/Principal Findings</title><p>We show in the mouse model that naturally occurring sequence variations of the conserved nucleoprotein of the virus significantly impact cross-protection against lethal disease <italic>in vivo</italic>. When priming and challenge viruses shared identical sequences of the immunodominant, protective NP<sub>366</sub>/D<sup>b</sup> epitope, strong cross-subtype protection was observed. However, when they did not share complete sequence identity in this epitope, cross-protection was considerably reduced. Contributions of virus-specific antibodies appeared to be minimal under these circumstances. Detailed analysis revealed that the magnitude of the memory CD8 T cell response triggered by the NP<sub>366</sub>/D<sup>b</sup> variants was significantly lower than those triggered by the homologous NP<sub>366</sub>/D<sup>b</sup> ligand. It appears that strict specificity of a dominant public TCR to the original NP<sub>366</sub>/D<sup>b</sup> ligand may limit the expansion of cross-reactive memory CD8 T cells to the NP<sub>366</sub>/D<sup>b</sup> variants.</p></sec><sec><title>Conclusions/Significance</title><p>Pre-existing CD8 T cell immunity may provide substantial cross-protection against heterosubtypic influenza A viruses, provided that the priming and the subsequent challenge viruses share the identical sequences of the immunodominant, protective CTL epitopes.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schulman, Jl" uniqKey="Schulman J">JL Schulman</name></author><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshikawa, T" uniqKey="Yoshikawa T">T Yoshikawa</name></author><author><name sortKey="Matsuo, K" uniqKey="Matsuo K">K Matsuo</name></author><author><name sortKey="Matsuo, K" uniqKey="Matsuo K">K Matsuo</name></author><author><name sortKey="Suzuki, Y" uniqKey="Suzuki Y">Y Suzuki</name></author><author><name sortKey="Nomoto, A" uniqKey="Nomoto A">A Nomoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roose, K" uniqKey="Roose K">K Roose</name></author><author><name sortKey="Fiers, W" uniqKey="Fiers W">W Fiers</name></author><author><name sortKey="Saelens, X" uniqKey="Saelens X">X Saelens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshida, R" uniqKey="Yoshida R">R Yoshida</name></author><author><name sortKey="Igarashi, M" uniqKey="Igarashi M">M Igarashi</name></author><author><name sortKey="Ozaki, H" uniqKey="Ozaki H">H Ozaki</name></author><author><name sortKey="Kishida, N" uniqKey="Kishida N">N Kishida</name></author><author><name sortKey="Tomabechi, D" uniqKey="Tomabechi D">D Tomabechi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author><author><name sortKey="Hwang, Wc" uniqKey="Hwang W">WC Hwang</name></author><author><name sortKey="Perez, S" uniqKey="Perez S">S Perez</name></author><author><name sortKey="Wei, G" uniqKey="Wei G">G Wei</name></author><author><name sortKey="Aird, D" uniqKey="Aird D">D Aird</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, S" uniqKey="Liang S">S Liang</name></author><author><name sortKey="Mozdzanowska, K" uniqKey="Mozdzanowska K">K Mozdzanowska</name></author><author><name sortKey="Palladino, G" uniqKey="Palladino G">G Palladino</name></author><author><name sortKey="Gerhard, W" uniqKey="Gerhard W">W Gerhard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Powell, Tj" uniqKey="Powell T">TJ Powell</name></author><author><name sortKey="Strutt, T" uniqKey="Strutt T">T Strutt</name></author><author><name sortKey="Reome, J" uniqKey="Reome J">J Reome</name></author><author><name sortKey="Hollenbaugh, Ja" uniqKey="Hollenbaugh J">JA Hollenbaugh</name></author><author><name sortKey="Roberts, Ad" uniqKey="Roberts A">AD Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author><author><name sortKey="Renshaw, M" uniqKey="Renshaw M">M Renshaw</name></author><author><name sortKey="Clements, Jd" uniqKey="Clements J">JD Clements</name></author><author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen, Hh" uniqKey="Nguyen H">HH Nguyen</name></author><author><name sortKey="Van Ginkel, Fw" uniqKey="Van Ginkel F">FW van Ginkel</name></author><author><name sortKey="Vu, Hl" uniqKey="Vu H">HL Vu</name></author><author><name sortKey="Mcghee, Jr" uniqKey="Mcghee J">JR McGhee</name></author><author><name sortKey="Mestecky, J" uniqKey="Mestecky J">J Mestecky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molinari, Na" uniqKey="Molinari N">NA Molinari</name></author><author><name sortKey="Ortega Sanchez, Ir" uniqKey="Ortega Sanchez I">IR Ortega-Sanchez</name></author><author><name sortKey="Messonnier, Ml" uniqKey="Messonnier M">ML Messonnier</name></author><author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name></author><author><name sortKey="Wortley, Pm" uniqKey="Wortley P">PM Wortley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jameson, J" uniqKey="Jameson J">J Jameson</name></author><author><name sortKey="Cruz, J" uniqKey="Cruz J">J Cruz</name></author><author><name sortKey="Terajima, M" uniqKey="Terajima M">M Terajima</name></author><author><name sortKey="Ennis, Fa" uniqKey="Ennis F">FA Ennis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kreijtz, Jh" uniqKey="Kreijtz J">JH Kreijtz</name></author><author><name sortKey="De Mutsert, G" uniqKey="De Mutsert G">G de Mutsert</name></author><author><name sortKey="Van Baalen, Ca" uniqKey="Van Baalen C">CA van Baalen</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Ly" uniqKey="Lee L">LY Lee</name></author><author><name sortKey="Ha Do, La" uniqKey="Ha Do L">LA Ha do</name></author><author><name sortKey="Simmons, C" uniqKey="Simmons C">C Simmons</name></author><author><name sortKey="De Jong, Md" uniqKey="De Jong M">MD de Jong</name></author><author><name sortKey="Chau, Nv" uniqKey="Chau N">NV Chau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roti, M" uniqKey="Roti M">M Roti</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name></author><author><name sortKey="Berger, D" uniqKey="Berger D">D Berger</name></author><author><name sortKey="Huston, L" uniqKey="Huston L">L Huston</name></author><author><name sortKey="James, Ea" uniqKey="James E">EA James</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcmichael, A" uniqKey="Mcmichael A">A McMichael</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL Epstein</name></author><author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name></author><author><name sortKey="Misplon, Ja" uniqKey="Misplon J">JA Misplon</name></author><author><name sortKey="Lo, Cy" uniqKey="Lo C">CY Lo</name></author><author><name sortKey="Cooper, La" uniqKey="Cooper L">LA Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoelscher, Ma" uniqKey="Hoelscher M">MA Hoelscher</name></author><author><name sortKey="Garg, S" uniqKey="Garg S">S Garg</name></author><author><name sortKey="Bangari, Ds" uniqKey="Bangari D">DS Bangari</name></author><author><name sortKey="Belser, Ja" uniqKey="Belser J">JA Belser</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gorman, Ot" uniqKey="Gorman O">OT Gorman</name></author><author><name sortKey="Bean, Wj" uniqKey="Bean W">WJ Bean</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hiromoto, Y" uniqKey="Hiromoto Y">Y Hiromoto</name></author><author><name sortKey="Yamazaki, Y" uniqKey="Yamazaki Y">Y Yamazaki</name></author><author><name sortKey="Fukushima, T" uniqKey="Fukushima T">T Fukushima</name></author><author><name sortKey="Saito, T" uniqKey="Saito T">T Saito</name></author><author><name sortKey="Lindstrom, Se" uniqKey="Lindstrom S">SE Lindstrom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boon, Ac" uniqKey="Boon A">AC Boon</name></author><author><name sortKey="De Mutsert, G" uniqKey="De Mutsert G">G de Mutsert</name></author><author><name sortKey="Graus, Ym" uniqKey="Graus Y">YM Graus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Sintnicolaas, K" uniqKey="Sintnicolaas K">K Sintnicolaas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voeten, Jt" uniqKey="Voeten J">JT Voeten</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Nieuwkoop, Nj" uniqKey="Nieuwkoop N">NJ Nieuwkoop</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boon, Ac" uniqKey="Boon A">AC Boon</name></author><author><name sortKey="De Mutsert, G" uniqKey="De Mutsert G">G de Mutsert</name></author><author><name sortKey="Van Baarle, D" uniqKey="Van Baarle D">D van Baarle</name></author><author><name sortKey="Smith, Dj" uniqKey="Smith D">DJ Smith</name></author><author><name sortKey="Lapedes, As" uniqKey="Lapedes A">AS Lapedes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crowe, Sr" uniqKey="Crowe S">SR Crowe</name></author><author><name sortKey="Miller, Sc" uniqKey="Miller S">SC Miller</name></author><author><name sortKey="Brown, Dm" uniqKey="Brown D">DM Brown</name></author><author><name sortKey="Adams, Ps" uniqKey="Adams P">PS Adams</name></author><author><name sortKey="Dutton, Rw" uniqKey="Dutton R">RW Dutton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, W" uniqKey="Zhong W">W Zhong</name></author><author><name sortKey="Reche, Pa" uniqKey="Reche P">PA Reche</name></author><author><name sortKey="Lai, Cc" uniqKey="Lai C">CC Lai</name></author><author><name sortKey="Reinhold, B" uniqKey="Reinhold B">B Reinhold</name></author><author><name sortKey="Reinherz, El" uniqKey="Reinherz E">EL Reinherz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belz, Gt" uniqKey="Belz G">GT Belz</name></author><author><name sortKey="Xie, W" uniqKey="Xie W">W Xie</name></author><author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crowe, Sr" uniqKey="Crowe S">SR Crowe</name></author><author><name sortKey="Miller, Sc" uniqKey="Miller S">SC Miller</name></author><author><name sortKey="Woodland, Dl" uniqKey="Woodland D">DL Woodland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meijers, R" uniqKey="Meijers R">R Meijers</name></author><author><name sortKey="Lai, Cc" uniqKey="Lai C">CC Lai</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Liu, Jh" uniqKey="Liu J">JH Liu</name></author><author><name sortKey="Zhong, W" uniqKey="Zhong W">W Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, Ly" uniqKey="Lu L">LY Lu</name></author><author><name sortKey="Askonas, Ba" uniqKey="Askonas B">BA Askonas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Townsend, Ar" uniqKey="Townsend A">AR Townsend</name></author><author><name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klenerman, P" uniqKey="Klenerman P">P Klenerman</name></author><author><name sortKey="Zinkernagel, Rm" uniqKey="Zinkernagel R">RM Zinkernagel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mongkolsapaya, J" uniqKey="Mongkolsapaya J">J Mongkolsapaya</name></author><author><name sortKey="Dejnirattisai, W" uniqKey="Dejnirattisai W">W Dejnirattisai</name></author><author><name sortKey="Xu, Xn" uniqKey="Xu X">XN Xu</name></author><author><name sortKey="Vasanawathana, S" uniqKey="Vasanawathana S">S Vasanawathana</name></author><author><name sortKey="Tangthawornchaikul, N" uniqKey="Tangthawornchaikul N">N Tangthawornchaikul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kedzierska, K" uniqKey="Kedzierska K">K Kedzierska</name></author><author><name sortKey="Turner, Sj" uniqKey="Turner S">SJ Turner</name></author><author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, W" uniqKey="Zhong W">W Zhong</name></author><author><name sortKey="Reinherz, El" uniqKey="Reinherz E">EL Reinherz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, W" uniqKey="Zhong W">W Zhong</name></author><author><name sortKey="Dixit, Sb" uniqKey="Dixit S">SB Dixit</name></author><author><name sortKey="Mallis, Rj" uniqKey="Mallis R">RJ Mallis</name></author><author><name sortKey="Arthanari, H" uniqKey="Arthanari H">H Arthanari</name></author><author><name sortKey="Lugovskoy, Aa" uniqKey="Lugovskoy A">AA Lugovskoy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kendal, Ap" uniqKey="Kendal A">AP Kendal</name></author><author><name sortKey="Pereira, Ms" uniqKey="Pereira M">MS Pereira</name></author><author><name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Young, Sa" uniqKey="Young S">SA Young</name></author><author><name sortKey="Galphin, Jc" uniqKey="Galphin J">JC Galphin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Zhong, Weimin" sort="Zhong, Weimin" uniqKey="Zhong W" first="Weimin" last="Zhong">Weimin Zhong</name></region><name sortKey="Dong, Libo" sort="Dong, Libo" uniqKey="Dong L" first="Libo" last="Dong">Libo Dong</name><name sortKey="Hancock, Kathy" sort="Hancock, Kathy" uniqKey="Hancock K" first="Kathy" last="Hancock">Kathy Hancock</name><name sortKey="Katz, Jacqueline M" sort="Katz, Jacqueline M" uniqKey="Katz J" first="Jacqueline M." last="Katz">Jacqueline M. Katz</name><name sortKey="Liu, Feng" sort="Liu, Feng" uniqKey="Liu F" first="Feng" last="Liu">Feng Liu</name><name sortKey="Lu, Xiuhua" sort="Lu, Xiuhua" uniqKey="Lu X" first="Xiuhua" last="Lu">Xiuhua Lu</name><name sortKey="Reinherz, Ellis L" sort="Reinherz, Ellis L" uniqKey="Reinherz E" first="Ellis L." last="Reinherz">Ellis L. Reinherz</name><name sortKey="Sambhara, Suryaprakash" sort="Sambhara, Suryaprakash" uniqKey="Sambhara S" first="Suryaprakash" last="Sambhara">Suryaprakash Sambhara</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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